This domain is found exclusively in uncharacterised proteins from Legionellales species. It contains several highly conserved cysteine residues which are predicted to form disulfide bonds. It is composed of two repeats predicted to consist of a small three-stranded antiparallel beta-sheet and an alpha-helix packed on it.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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