This domain is found in uncharacterised fungal proteins. It contains two pairs of highly conserved cysteine residues that are likely involved in metal coordination. This domain is predicted to fold into a structure which closely resembles domains members of the Zn(2)-Cys(6) binuclear cluster superfamily. Despite its conserved residues occupy equivalent spacial positions as the metal coordinating residues in Zn(2)-Cys(6) domains, this domain contains only four cysteines of six suggesting it can only coordinate one zinc atom.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":91,"pathways":0,"proteins":91,"proteomes":52,"sets":0,"structural_models":{"alphafold":63},"structures":0,"taxa":130},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":61},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}