This domain is found in uncharacterised eukaryotic proteins. It share similarity with known CHORD domains and it is predicted to adopt similar structure. In some proteins it is found in combination with AAA+ domains [pfam:PF00004]. It contains several cysteine and histidine residues which are highly conserved and likely involved in metal coordination.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0921","name":"CHORD-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":113,"pathways":0,"proteins":113,"proteomes":43,"sets":1,"structural_models":{"alphafold":106},"structures":0,"taxa":124},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":29,"alignment:full":139},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}