This entry describes a set of proteins of unknown function, mainly from Dictyostelium discoideum. These uncharacterised proteins display a CUB-like fold, a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins [[cite:PUB00035659]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00035659":{"PMID":17446170,"ISBN":null,"volume":"282","issue":"23","year":2007,"title":"Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity.","URL":null,"raw_pages":"16924-33","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Blanc G","Font B","Eichenberger D","Moreau C","Ricard-Blum S","Hulmes DJ","Moali C."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M701610200"}},"set_info":{"accession":"CL0164","name":"CUB"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":37,"pathways":0,"proteins":37,"proteomes":16,"sets":1,"structural_models":{"alphafold":28},"structures":0,"taxa":54},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":26},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}