This entry represents a domain from a family of uncharacterised proteins in archaea, specifically within the Halobacteria class. The proteins in this family are typically around 116 amino acids in length. They are predicted to be integral membrane proteins, as suggested by the presence of four predicted transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":12,"pathways":0,"proteins":12,"proteomes":12,"sets":0,"structural_models":{"alphafold":12},"structures":0,"taxa":39},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":5},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}