This entry represents a domain from a family of uncharacterised proteins in the class Halobacteria. The proteins containing this domain are predominantly found in various genera within the Halobacteriales order. The domain is typically found in proteins ranging from 129 to 225 amino acids in length. These proteins are predicted to be integral membrane proteins, as suggested by the presence of two transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":145,"pathways":0,"proteins":145,"proteomes":96,"sets":0,"structural_models":{"alphafold":139},"structures":0,"taxa":167},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":60},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}