This domain is found in uncharacterised plant proteins. It is predicted to fold into an open barrel-like structure. It contains two pair of conserved cysteine residues which are predicted to form disulfide bonds. It may be involve in oligomerisation given the number of conserved exposed hydrophobic residues.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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