{"metadata":{"accession":"PF26607","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR058502","hierarchy":null,"name":{"name":"PLL-like beta propeller","short":"Beta-prop_PLL"},"description":[{"text":"<p>This domain, previously known as DUF8189, is found in the L-fucose-binding lectins PHL and PLLs(1-5) from various Photorhabdus species and their homologues. This domain forms a seven-bladed beta-propeller [[cite:PUB00100843],[cite:PUB00109482],[cite:PUB00161611]]. Each blade makes a W-motif composed of four antiparallel beta-strands (beta1-beta4) connected by beta-turns and loops. The C and N terminus are located on the same side of the torus and create a cap of the inner cavity of the torus. With exception of PLL3, which is a monomer, all other domains assemble into oligomeric structures, either homo-dimeric or homo-tetrameric, connected with an inter-subunit disulfide bridge [[cite:PUB00100843],[cite:PUB00109482],[cite:PUB00161611]]. Besides L-fucose or fucosylated saccharides, some of these domains bind to unusual O-methylated disaccharide 3,6-O-Me2-d-Glc-beta1-4(2,3-O-Me2)-l-Rha-alpha (MGMR) [[cite:PUB00161611]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100843":{"PMID":27758853,"ISBN":null,"volume":"291","issue":"48","year":2016,"title":"A Novel Fucose-binding Lectin from Photorhabdus luminescens (PLL) with an Unusual Heptabladed β-Propeller Tetrameric Structure.","URL":null,"raw_pages":"25032-25049","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Kumar A","Sykorova P","Demo G","Dobes P","Hyrsl P","Wimmerova M."],"DOI_URL":null},"PUB00109482":{"PMID":28806750,"ISBN":null,"volume":"13","issue":"8","year":2017,"title":"Characterization of novel bangle lectin from Photorhabdus asymbiotica with dual sugar-binding specificity and its effect on host immunity.","URL":null,"raw_pages":"e1006564","medline_journal":"PLoS Pathog","ISO_journal":"PLoS Pathog","authors":["Jancarikova G","Houser J","Dobes P","Demo G","Hyrsl P","Wimmerova M."],"DOI_URL":null},"PUB00161611":{"PMID":40459235,"ISBN":null,"volume":"35","issue":"7","year":2025,"title":"The insight into the biology of five homologous lectins produced by the entomopathogenic bacterium and nematode symbiont Photorhabdus laumondii.","URL":null,"raw_pages":"cwaf033","medline_journal":"Glycobiology","ISO_journal":"Glycobiology","authors":["Paulenova E","Dobes P","Melicher F","Houser J","Faltinek L","Hyrsl P","Wimmerova M."],"DOI_URL":"https://doi.org/10.1093/glycob/cwaf033"}},"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":208,"interactions":0,"matches":3660,"pathways":0,"proteins":3295,"proteomes":1819,"sets":1,"structural_models":{"alphafold":1884},"structures":31,"taxa":3095},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":2194},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8q82","name":"Photorhabdus laumondii lectin PLL4 in complex with alpha-methyl-fucoside"}}}