This entry represents the central domain found in a family of uncharacterised proteins from archaea. The proteins are predominantly found in the Halobacteria class, which includes members of the Haloferacaceae, Haloarculaceae, and Natrialbaceae families. The proteins in this family are typically around 550-580 amino acids in length.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":260,"pathways":0,"proteins":260,"proteomes":156,"sets":0,"structural_models":{"alphafold":236},"structures":0,"taxa":259},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":44,"alignment:full":78},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}