This entry represents a domain from a family of uncharacterised proteins in the archaeal phylum Thermoproteota. The proteins are predominantly found in the order Sulfolobales, which includes genera such as Acidianus, Metallosphaera, and Sulfolobus. The domain is approximately 110 amino acids in length. The reviewed protein SSO0428 from Saccharolobus solfataricus is a representative member of this family. Proteins in this family are predicted to form a single long alpha helix. Structure prediction suggests that this protein does not form a homomeric coiled-coil complex. Based on genomic context this protein may be an accessory subunit of the V-type ATP synthase complex.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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