This entry represents a domain from a family of uncharacterised proteins predominantly found in the class Clostridia. The proteins containing this domain are typically between 60 and 130 amino acids in length. The domain is highly conserved across various species within the Bacillota and Thermodesulfobacteriota phyla. Structure prediction suggests this protein is composed of two alpha helices and forms a head to tail dimer conformation. The sequences contain a set of histidines in helix one that according to AlphaFold 3 confidently binds to a zinc ion.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":280,"pathways":0,"proteins":280,"proteomes":256,"sets":0,"structural_models":{"alphafold":203},"structures":0,"taxa":541},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":116,"alignment:full":166},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}