This entry represents the C-terminal domain from a family of uncharacterised proteins in Methanobacteriota. The proteins are predominantly found in archaea, specifically within the Methanobacteriota phylum. This includes orders such as Methanobacteriales, Methanosarcinales, and Methanomicrobiales. The proteins in this family are approximately 500 amino acids in length. This domain shows structural similarity to cyclophilin type peptidyl-prolyl cis-trans isomerases. Domains 2 and 3 in these proteins also adopt the same fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0475","name":"Cyclophil-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":162,"pathways":0,"proteins":162,"proteomes":159,"sets":1,"structural_models":{"alphafold":142},"structures":3,"taxa":304},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":71,"alignment:full":77},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}