This entry represents an alpha helical domain from a family of uncharacterised proteins in the Stenosarchaea group. The proteins in this family are primarily found in archaea, particularly within the Halobacteriales and Methanobacteriota. The domain is approximately 180 amino acids in length. Proteins containing this domain are predicted to be integral membrane proteins, as suggested by the presence of multiple transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":931,"pathways":0,"proteins":931,"proteomes":712,"sets":0,"structural_models":{"alphafold":766},"structures":0,"taxa":1494},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":19,"alignment:full":529},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}