This entry represents a domain from a family of uncharacterised proteins in archaea. The proteins containing this domain are predominantly found in members of the Halobacteria class, including families such as Haloarculaceae, Natrialbaceae, and Haloferacaceae. The domain is typically found in proteins ranging from approximately 240 to 300 amino acids in length. This domain shows structural similarity to the Csm1 protein covering the HD-like domain and domain A [[cite:PUB00091420]]. This finding suggests that this domain may have DNase activity.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00091420":{"PMID":25773141,"ISBN":null,"volume":"23","issue":"4","year":2015,"title":"Crystal structure of the Csm1 subunit of the Csm complex and its single-stranded DNA-specific nuclease activity.","URL":null,"raw_pages":"782-90","medline_journal":"Structure","ISO_journal":"Structure","authors":["Jung TY","An Y","Park KH","Lee MH","Oh BH","Woo E."],"DOI_URL":"https://doi.org/10.1016/j.str.2015.01.021"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":94,"pathways":0,"proteins":94,"proteomes":75,"sets":0,"structural_models":{"alphafold":81},"structures":0,"taxa":143},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":47},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}