This entry represents the N-terminal integral membrane domain of a family of uncharacterised proteins from halophilic archaea that contain four domains. The proteins in this family are predominantly found in the class Halobacteria, which includes families such as Haloferacaceae, Natrialbaceae, and Haloarculaceae. These proteins are typically around 400 amino acids in length. This domain contains three predicted transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":543,"pathways":0,"proteins":543,"proteomes":247,"sets":0,"structural_models":{"alphafold":513},"structures":0,"taxa":388},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":147,"alignment:full":210},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}