This entry represents a domain from a family of uncharacterised proteins found in both cyanobacteria and archaea. The domain is present in a wide range of species, including members of the Leptolyngbya group and Halobacteria. Proteins containing this domain are typically around 200 amino acids in length. The domain is highly conserved across different species, suggesting a potentially important but yet unidentified function.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":110,"pathways":0,"proteins":104,"proteomes":104,"sets":0,"structural_models":{"alphafold":86},"structures":0,"taxa":293},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":97},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}