This entry represents a domain from a family of uncharacterised proteins in Halobacteria. The domain is predominantly found in archaea, with a notable presence in the Halorubrum genus. Proteins containing this domain are typically between 150 and 190 amino acids in length. The domain is predicted to be part of integral membrane proteins with four predicted transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":59,"pathways":0,"proteins":59,"proteomes":53,"sets":0,"structural_models":{"alphafold":59},"structures":0,"taxa":105},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":26},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}