This entry represents a domain from a family of uncharacterised proteins in halophilic archaea. The proteins are predominantly found in the Halobacteria class, including families such as Haloferacaceae and Natrialbaceae. The domain is approximately 70 amino acids in length. Reviewed UniProt entry Q18JS4 from Haloquadratum walsbyi contains this domain. This domain is likely to be zinc binding based on conservation of cysteine and histidine residues.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":218,"pathways":0,"proteins":218,"proteomes":217,"sets":0,"structural_models":{"alphafold":210},"structures":0,"taxa":328},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":46,"alignment:full":92},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}