This entry represents a domain from a family of uncharacterised proteins in the Halobacteria class. These proteins are predominantly found in various families within the Methanobacteriota phylum, including Haloferacaceae, Haloarculaceae, and Natrialbaceae. The proteins in this family are typically between 70 to 100 amino acids in length. They are predicted to be integral membrane proteins, often featuring two transmembrane helices. The reviewed protein from Haloferax volcanii ([swissprot:D4GZ12]) is an example of this domain's occurrence.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":179,"pathways":0,"proteins":179,"proteomes":179,"sets":0,"structural_models":{"alphafold":170},"structures":0,"taxa":283},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":52,"alignment:full":73},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}