This entry represents a pair of domains found in family of uncharacterised proteins from halophilic archaea. Based on structural similarity of other domains in these proteins this family may represents a family of primase proteins. This entry represents a pair of protein domains with one nested within the loop of another. The proteins in this family are predominantly found in the class Halobacteria, which includes families such as Natrialbaceae, Halobacteriaceae, and Haloarculaceae. The proteins are typically around 500 amino acids in length. Many of these proteins are encoded on plasmids, suggesting a potential role in plasmid-associated functions.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":108,"pathways":0,"proteins":108,"proteomes":83,"sets":0,"structural_models":{"alphafold":103},"structures":0,"taxa":167},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":34},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}