This entry represents a domain from a family of uncharacterised proteins found in archaea. The proteins in this family are predominantly found in the class Halobacteria, which includes genera such as Halorubrum, Natronorubrum, and Halovenus. The proteins containing this domain vary in length, with sequences ranging from approximately 59 to 347 amino acids. The structure of this domain adopts an alpha solenoid.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":68,"pathways":0,"proteins":68,"proteomes":45,"sets":1,"structural_models":{"alphafold":64},"structures":0,"taxa":95},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":17},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}