This entry represents a domain from a family of uncharacterised proteins in archaea. The proteins in this family are predominantly found in halophilic archaea, including members of the Halobacteriales order. Proteins containing this domain are typically around 140 amino acids in length. The domain is predicted to be part of integral membrane proteins, as suggested by the presence of multiple transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":35,"pathways":0,"proteins":35,"proteomes":35,"sets":0,"structural_models":{"alphafold":32},"structures":0,"taxa":58},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":10},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}