This entry represents a domain from a family of uncharacterised proteins in archaea. The domain is predominantly found in the class Halobacteria, which includes species from families such as Natrialbaceae and Haloferacaceae. The proteins containing this domain are typically around 60-70 amino acids in length. The domain contains two transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":204,"pathways":0,"proteins":204,"proteomes":190,"sets":0,"structural_models":{"alphafold":195},"structures":0,"taxa":304},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":55,"alignment:full":83},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}