This entry represents a domain from a family of uncharacterised proteins in halophilic archaea. The proteins containing this domain are primarily found in the class Halobacteria, which includes various families such as Haloferacaceae, Halobacteriaceae, and Natrialbaceae. These proteins are typically around 190-200 amino acids in length. The domain shows a high overlap with TED domains, suggesting a conserved structure. Several proteins in this family are predicted to be lipoproteins, indicating a potential association with membranes. This domain adopts an Ig-like fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":98,"pathways":0,"proteins":98,"proteomes":85,"sets":1,"structural_models":{"alphafold":87},"structures":0,"taxa":158},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":43},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}