This entry represents a family of uncharacterised proteins found in various archaea, particularly within the Halobacteria class. The proteins in this family are typically around 340 amino acids in length. According to the TED database these proteins are composed of three domains that are nested within each other. The outer domain is composed of six transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":166,"pathways":0,"proteins":166,"proteomes":111,"sets":0,"structural_models":{"alphafold":159},"structures":0,"taxa":205},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":58},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}