This entry represents the C-terminal domain of a family of uncharacterised proteins from archaea. The proteins in this family are primarily found in the Halobacteria class, including members of the Halorubrum and Haloferax genera. The family is also present in various viruses that infect these archaea. The proteins are typically around 250 to 280 amino acids in length. Many of these proteins are predicted to be membrane-associated, featuring one or more transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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