This entry represents a domain from a family of uncharacterised proteins in Halobacteria. The proteins containing this domain are predominantly found in various genera within the Haloferacaceae family, including Halonotius, Halorubrum, and others. The domain is typically found in proteins ranging from approximately 88 to 133 amino acids in length. The reviewed protein D4GXW3 from Haloferax volcanii contains this domain. This domain is composed of a four stranded beta sheet with alpha helices packed on one side.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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