This entry represents a the central transmembrane domain from family of uncharacterised proteins from halophilic archaea. The family is predominantly found in the class Halobacteria, which includes members from the families Natrialbaceae and Haloferacaceae. Proteins in this family are typically between 150 and 350 amino acids in length. They are predicted to be membrane-associated, as suggested by the presence of two transmembrane helices represented by this domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":65,"pathways":0,"proteins":65,"proteomes":62,"sets":0,"structural_models":{"alphafold":63},"structures":0,"taxa":123},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":31},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}