This entry represents a domain from a family of uncharacterised proteins in archaea. The proteins containing this domain are predominantly found in the class Halobacteria, which includes genera such as Halalkalicoccus, Haladaptatus, and Natrialbaceae. The domain is typically found in proteins ranging from approximately 60 to 200 amino acids in length. This domain contains conserved cysteine residues suggestive of zinc binding. Some proteins in this family are predicted to contain transmembrane helices, suggesting a possible membrane-associated role.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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