This entry represents a domain from a family of uncharacterised proteins in archaea. The proteins in this family are predominantly found in the class Halobacteria, which are known for their adaptation to high-salt environments. The proteins in this family are generally around 130 amino acids in length. Structure prediction with AlphaFold 3 suggests that proteins in this family may form intertwined homodimers [swissprot:B9LW05] (ipTM=0.68 pTM=0.69).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":84,"pathways":0,"proteins":84,"proteomes":68,"sets":0,"structural_models":{"alphafold":77},"structures":0,"taxa":160},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":16,"alignment:full":23},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}