This entry represents a family of uncharacterised proteins found predominantly in halophilic archaea. The proteins in this family are primarily distributed among the Halobacteria class, including families such as Haloferacaceae and Haloarculaceae. The domain is typically found in proteins ranging from 170 to 230 amino acids in length. Many of these proteins exhibit regions of disorder, particularly towards the C-terminal end, which are rich in acidic residues. According to the TED database proteins in this family are composed of three small domains.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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