This entry represents a domain from a family of uncharacterised proteins in archaea. The proteins containing this domain are predominantly found in the class Halobacteria, which includes genera such as Halorubrum, Haloarculaceae, and Haloferacaceae. These proteins are typically found in extreme halophilic environments. The proteins in this family generally range from 88 to 138 amino acids in length. AlphaFold3 predicts this protein can form a homodimer [swissprot:U1Q8T4] (ipTM=0.81 pTM=0.81) which is composed of a four stranded beta sheet with a pair of helices packed on one side and two stacked pairs of helices on the other.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":138,"pathways":0,"proteins":138,"proteomes":126,"sets":0,"structural_models":{"alphafold":132},"structures":0,"taxa":207},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":55},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}