This entry represents the C-terminal alpha-helical domain from a family of putative primase protein in halophilic archaea. The proteins in this family are predominantly found in the class Halobacteria, which includes several families such as Haloferacaceae, Halobacteriaceae, and Natrialbaceae. The proteins containing this domain are typically around 500 amino acids in length, as observed in several sequences from the SEED alignment. This domain is associated with proteins that are often encoded on plasmids in various halophilic archaea.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0242","name":"DNA_primase_lrg"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":115,"pathways":0,"proteins":114,"proteomes":88,"sets":1,"structural_models":{"alphafold":108},"structures":0,"taxa":170},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":36},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}