This entry represents a domain from a family of uncharacterised proteins in archaea. The proteins containing this domain are predominantly found in the class Halobacteria, which are known for their extreme halophilic nature. The domain is typically found in proteins ranging from 59 to 80 amino acids in length. Proteins containing this domain are predicted to be integral membrane proteins, as suggested by the presence of multiple transmembrane helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":214,"pathways":0,"proteins":214,"proteomes":214,"sets":0,"structural_models":{"alphafold":208},"structures":0,"taxa":341},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":79,"alignment:full":88},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}