This entry represents a domain from a family of uncharacterised proteins found predominantly in the Halobacteria class of Archaea. The proteins containing this domain are primarily distributed among members of the Haloarculaceae and Haloferacaceae families. The domain is typically found in proteins ranging from 85 to 117 amino acids in length. The domain adopts a four helical bundle structure.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":91,"pathways":0,"proteins":91,"proteomes":91,"sets":0,"structural_models":{"alphafold":82},"structures":0,"taxa":150},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":28},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}