{"metadata":{"accession":"PF26402","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR058413","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8100)","short":"DUF8100"},"description":[{"text":"<p>This entry represents a domain from a family of uncharacterised proteins in the Halobacteria class of Archaea. Proteins in this family are predominantly found in the order Halobacteriales, including genera such as Halobacterium, Haladaptatus, and Halonotius. The proteins in this family typically range from 145 to 227 amino acids in length. These proteins are predicted to be integral membrane proteins, as they contain multiple transmembrane helices.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":27,"pathways":0,"proteins":27,"proteomes":24,"sets":0,"structural_models":{"alphafold":26},"structures":0,"taxa":57},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":12},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}