This entry describes a domain of unknown function in putative HSP20-like chaperone proteins mostly found in plants. HSP20-like chaperones are a ubiquitous and abundant class of small Heat shock proteins (sHsps) that function as ATP-independent molecular chaperones in plants, protecting proteins from stress-induced denaturation and aggregation [[cite:PUB00161222]]. This domain contains a helix-turn-helix (HTH) like fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00161222":{"PMID":31992813,"ISBN":null,"volume":"10","issue":"1","year":2020,"title":"A class I cytosolic HSP20 of rice enhances heat and salt tolerance in different organisms.","URL":null,"raw_pages":"1383","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Guo LM","Li J","He J","Liu H","Zhang HM."],"DOI_URL":"https://doi.org/10.1038/s41598-020-58395-8"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":23,"interactions":0,"matches":1514,"pathways":0,"proteins":1503,"proteomes":369,"sets":0,"structural_models":{"alphafold":1207},"structures":0,"taxa":1003},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":19,"alignment:full":936},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}