{"metadata":{"accession":"PF26064","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR058336","hierarchy":null,"name":{"name":"VP3-like","short":"VP3"},"description":[{"text":"<p>This entry represents a family of uncharacterised integral membrane proteins found in DNA viruses that infect archaea and halobacteria, incuding Matrix protein Halorubrum pleomorphic virus 1 (VP3). These proteins contain four predicted transmembrane helices. These proteins have a pair of beta hairpin structures inserted between the first and second alpha helices. There is some evidence that this beta hairpin may mediate a homodimerisation interaction (AlphaFold3 W0JNP7 ipTM=0.7 pTM=0.74).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00161613":{"PMID":19864380,"ISBN":null,"volume":"84","issue":"2","year":2010,"title":"The single-stranded DNA genome of novel archaeal virus halorubrum pleomorphic virus 1 is enclosed in the envelope decorated with glycoprotein spikes.","URL":null,"raw_pages":"788-98","medline_journal":"J Virol","ISO_journal":"J Virol","authors":["Pietila MK","Laurinavicius S","Sund J","Roine E","Bamford DH."],"DOI_URL":"https://doi.org/10.1128/JVI.01347-09"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":254,"pathways":0,"proteins":252,"proteomes":171,"sets":0,"structural_models":{"alphafold":210},"structures":0,"taxa":352},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":67,"alignment:full":117},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}