This entry represents uncharacterised protein from Halogeometricum borinquense (Hbor_38910) and related archaeal proteins. This protein is found next to a toxic gene Hbor_38900 and is likely a immunity protein which is able to prevent self-intoxication [[cite:PUB00160456]]. This protein is predicted to adopt a complex alpha/beta structure with an unique topology.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00160456":{"PMID":39546591,"ISBN":null,"volume":"10","issue":"46","year":2024,"title":"Archaeal type six secretion system mediates contact-dependent antagonism.","URL":null,"raw_pages":"eadp7088","medline_journal":"Sci Adv","ISO_journal":"Sci Adv","authors":["Zachs T","Malit JJL","Xu J","Schurch A","Sivabalasarma S","Nußbaum P","Albers SV","Pilhofer M."],"DOI_URL":"https://doi.org/10.1126/sciadv.adp7088"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":336,"pathways":0,"proteins":270,"proteomes":39,"sets":0,"structural_models":{"alphafold":245},"structures":0,"taxa":84},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":31,"alignment:full":145},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}