This domain is found in uncharacterised protein from Halogeometricum borinquense (Hbor_03000) and related prokaryotic proteins. This protein is found next to a toxic gene Hbor_02990 and is likely a immunity protein which is able to prevent self-intoxication [[cite:PUB00160456]]. This domain is predicted to fold into three four-stranded beta-sheets that pack in a similar way as blades in beta-propellers.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00160456":{"PMID":39546591,"ISBN":null,"volume":"10","issue":"46","year":2024,"title":"Archaeal type six secretion system mediates contact-dependent antagonism.","URL":null,"raw_pages":"eadp7088","medline_journal":"Sci Adv","ISO_journal":"Sci Adv","authors":["Zachs T","Malit JJL","Xu J","Schurch A","Sivabalasarma S","Nußbaum P","Albers SV","Pilhofer M."],"DOI_URL":"https://doi.org/10.1126/sciadv.adp7088"}},"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":240,"pathways":0,"proteins":239,"proteomes":200,"sets":1,"structural_models":{"alphafold":159},"structures":0,"taxa":534},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":107},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}