The domain described by this entry is located towards the N-terminal in putative transmembrane and uncharacterised proteins found in plants. It is predicted to adopt a C2 fold. C2 domains are membrane-binding modules that share a common overall fold: a single compact greek-key motif organised as an eight-stranded anti-parallel beta-sandwich consisting of a pair of four-stranded beta-sheets [[cite:PUB00160608]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00160608":{"PMID":24745792,"ISBN":null,"volume":"1838","issue":"6","year":2014,"title":"Membrane structure and function: relevance of lipid and protein structures in cellular physiology, pathology and therapy.","URL":null,"raw_pages":"1449-50","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim Biophys Acta","authors":["Escriba PV","Nicolson GL."],"DOI_URL":"https://doi.org/10.1016/j.bbamem.2014.03.008"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":801,"pathways":0,"proteins":782,"proteomes":360,"sets":0,"structural_models":{"alphafold":641},"structures":0,"taxa":1018},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":40,"alignment:full":513},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}