This entry represents a domain of unknown function found in putative SANT domain-containing proteins and uncharacterised proteins found in plants. This domain is predicted to adopt an EF-hand-like fold. The EF-hand fold is a helix-loop-helix motif that can bind calcium atoms. The EF-hand fold is usually tandemly repeated, and the number of repeats ranges from two to eight [[cite:PUB00023098]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00023098":{"PMID":8602259,"ISBN":null,"volume":"380","issue":"6575","year":1996,"title":"Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.","URL":null,"raw_pages":"595-602","medline_journal":"Nature","ISO_journal":"Nature","authors":["Essen LO","Perisic O","Cheung R","Katan M","Williams RL."],"DOI_URL":"http://dx.doi.org/10.1038/380595a0"}},"set_info":{"accession":"CL0220","name":"EF_hand"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":29,"interactions":0,"matches":1598,"pathways":0,"proteins":1589,"proteomes":373,"sets":1,"structural_models":{"alphafold":1274},"structures":0,"taxa":1027},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":122,"alignment:full":1024},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}