This entry describes a domain of unknown function in putative EGF-like domain-containing proteins found in eukaryotes, mainly ameobas. According to structure predictions it adopts an EGF-like fold which contain six conserved cysteine residues. The EGF-like fold has two-stranded beta-sheets followed by a loop to a short C-termini. It usually occurs in tandem repeats [[cite:PUB00001555]]. The domain described by this entry has the 6 conserved cysteine residues. It also acquires a similar structure to the EGF-like fold and it is 40 amino acids long.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00001555":{"PMID":3282918,"ISBN":null,"volume":"231","issue":"1","year":1988,"title":"Structure and function of epidermal growth factor-like regions in proteins.","URL":null,"raw_pages":"1-4","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett.","authors":["Appella E","Weber IT","Blasi F."],"DOI_URL":"http://dx.doi.org/10.1016/0014-5793(88)80690-2"}},"set_info":{"accession":"CL0001","name":"EGF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":53,"interactions":0,"matches":358,"pathways":0,"proteins":347,"proteomes":12,"sets":1,"structural_models":{"alphafold":162},"structures":0,"taxa":62},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":50,"alignment:full":305},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}