This domain is found in uncharacterised bacterial proteins. It is predicted to fold into an alpha- helical bundle. This domain is found in the hypothetical protein ESA_00282 from Cronobacter sakazakii that plays a significant role in biofilm formation and bacterial adhesion. This protein contributes to the adhesion of C. sakazakii to biotic surfaces, such as intestinal epithelial cells and play a role in the pathogenesis [[cite:PUB00159769]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00159769":{"PMID":20118366,"ISBN":null,"volume":"76","issue":"7","year":2010,"title":"Genes involved in Cronobacter sakazakii biofilm formation.","URL":null,"raw_pages":"2251-61","medline_journal":"Appl Environ Microbiol","ISO_journal":"Appl Environ Microbiol","authors":["Hartmann I","Carranza P","Lehner A","Stephan R","Eberl L","Riedel K."],"DOI_URL":"https://doi.org/10.1128/AEM.00930-09"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":126,"pathways":0,"proteins":126,"proteomes":126,"sets":0,"structural_models":{"alphafold":76},"structures":0,"taxa":185},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":25},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}