{"metadata":{"accession":"PF25637","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR057702","hierarchy":null,"name":{"name":"Family of unknown function (DUF7942)","short":"DUF7942"},"description":[{"text":"<p>This family of uncharacterised bacterial proteins is found mainly in Actinomycetes. Members of this family are predicted to contain three transmembrane helices. A member of this family, SCO4225, is a putative integral membrane protein found in Streptomyces coelicolor, [swissprot:Q9FCE5]. The gene encoding SCO4225 is part of a cluster of genes (phoU to sco4225) that are involved in phosphate regulation and metabolism. This gene cluster is regulated by the two-component system PhoR-PhoP, which responds to phosphate availability in the environment [[cite:PUB00159567]]. The expression of SCO4225 is directly regulated by MacR, a response regulator that binds to a specific sequence in the promoter region of SCO4225. This regulation links SCO4225 to other genes in the MacR regulon, many of which are also membrane proteins [[cite:PUB00159414]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00159414":{"PMID":30530707,"ISBN":null,"volume":"85","issue":"4","year":2019,"title":"Novel Two-Component System MacRS Is a Pleiotropic Regulator That Controls Multiple Morphogenic Membrane Protein Genes in <i>Streptomyces coelicolor</i>.","URL":null,"raw_pages":"e02178-18","medline_journal":"Appl Environ Microbiol","ISO_journal":"Appl Environ Microbiol","authors":["Liu M","Zhang P","Zhu Y","Lu T","Wang Y","Cao G","Shi M","Chen XL","Tao M","Pang X."],"DOI_URL":"https://doi.org/10.1128/AEM.02178-18"},"PUB00159567":{"PMID":22466952,"ISBN":null,"volume":"95","issue":"6","year":2012,"title":"Transcriptional and preliminary functional analysis of the six genes located in divergence of phoR/phoP in Streptomyces lividans.","URL":null,"raw_pages":"1553-66","medline_journal":"Appl Microbiol Biotechnol","ISO_journal":"Appl Microbiol Biotechnol","authors":["Darbon E","Martel C","Nowacka A","Pegot S","Moreau PL","Virolle MJ."],"DOI_URL":"https://doi.org/10.1007/s00253-012-3995-2"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":654,"pathways":0,"proteins":608,"proteomes":487,"sets":0,"structural_models":{"alphafold":245},"structures":0,"taxa":641},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":170,"alignment:full":289},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}