This domain of unknown function is found in multiple copies in a number of bacterial proteins. It is closely related to domains represented by DUF11 ([pfam:PF01345]). Some members, similarly to DUF11, contains a conserved N-terminal lysine and a C-terminal asparagine with central aspartate/glutamate residues suggesting that they may contain an isopeptide bond.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":344,"interactions":0,"matches":1854,"pathways":0,"proteins":706,"proteomes":570,"sets":1,"structural_models":{"alphafold":239},"structures":0,"taxa":1090},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":1239},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}