This entry describes a domain of unknown function located at the N-terminal of proteins mostly found in fungi. According to structure predictions it might adopt an immunoglobulin, fibronectin type III fold. It is formed of two antiparallel beta-sheets stacked against each other, forming a beta-sandwich [[cite:PUB00158558]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00158558":{"PMID":20176268,"ISBN":null,"volume":"125","issue":"2 Suppl 2","year":2010,"title":"Structure and function of immunoglobulins.","URL":null,"raw_pages":"S41-52","medline_journal":"J Allergy Clin Immunol","ISO_journal":"J Allergy Clin Immunol","authors":["Schroeder HW Jr","Cavacini L."],"DOI_URL":"https://doi.org/10.1016/j.jaci.2009.09.046"}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":318,"pathways":0,"proteins":290,"proteomes":187,"sets":1,"structural_models":{"alphafold":187},"structures":0,"taxa":578},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":258},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}