This domain is found in uncharacterised bacterial proteins mainly from Actinomycetes. It is predicted to fold into a beta-sandwich with topological similarity to domains members of the adhesin superfamily. Most members contain conserved lysine aspartate and asparagine residues that are likely to form an isopeptide bond. This domain is frequently found in combination with DUF5979.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0204","name":"Adhesin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":28,"interactions":0,"matches":96,"pathways":0,"proteins":96,"proteomes":38,"sets":1,"structural_models":{"alphafold":60},"structures":0,"taxa":79},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":68,"alignment:full":81},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}