{"metadata":{"accession":"PF25536","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR057680","hierarchy":null,"name":{"name":"Domain of unknown function (DUF7920)","short":"DUF7920"},"description":[{"text":"<p>This entry represents a domain of unknown function found mostly in Trypanosoma. According to structure predictions it could adopt an ATP-grasp fold which is characterised by two alpha-beta subdomains that grasp the ATP molecules between them [[cite:PUB00020972],[cite:PUB00015342]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00020972":{"PMID":9416615,"ISBN":null,"volume":"6","issue":"12","year":1997,"title":"A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity.","URL":null,"raw_pages":"2639-43","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Galperin MY","Koonin EV."],"DOI_URL":"http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=9416615&action=stream&blobtype=pdf"},"PUB00015342":{"PMID":7862655,"ISBN":null,"volume":"92","issue":"4","year":1995,"title":"A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli.","URL":null,"raw_pages":"1172-6","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Fan C","Moews PC","Shi Y","Walsh CT","Knox JR."],"DOI_URL":"http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=7862655"}},"set_info":{"accession":"CL0179","name":"ATP-grasp"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":16,"interactions":0,"matches":258,"pathways":0,"proteins":194,"proteomes":137,"sets":1,"structural_models":{"alphafold":165},"structures":0,"taxa":493},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":156},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}