{"metadata":{"accession":"PF25509","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR057238","hierarchy":null,"name":{"name":"Domain of unknown function (DUF7916)","short":"DUF7916"},"description":[{"text":"<p>This domain is found in uncharacterised bacterial proteins. It is predicted to adopt a TIM-barrel structure. It shares detectable similarity with Mycobacterium tuberculosis Indole-3-glycerol phosphate synthase (TrpC).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0036","name":"TIM_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":809,"pathways":0,"proteins":809,"proteomes":720,"sets":1,"structural_models":{"alphafold":532},"structures":0,"taxa":1300},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":253,"alignment:full":385},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}